COVID 19 Delta variant may have increased ability to evade vaccine-induced immunity - دلتا سویه مقاوم تر کرونا در برابر واکسن

Vaccines are effective in decreasing hospitalization and deaths from COVID-19 infection but the emergence of viral variants of concern may diminish their efficacy. A study publishing in PLOS Pathogens by Emma Thomson, Brian Willett, and colleagues at the MRC-University of Glasgow Centre for Virus Research, United Kingdom and colleagues suggests that COVID-19 Delta variant may be more successful at evading the protective response of vaccines.

Mutations change the shape of the COVID-19 spike protein, preventing antibody recognition and enabling the virus to escape vaccine-induced immunity; however, the extent to which vaccine recipients are immune from the Delta variant is unknown. To quantify the capacity of different variants (Alpha, Beta and Delta) to evade protective immune response in vaccines, researchers analyzed serum samples collected from healthy people who had received either the Pfizer or Astra Zeneca vaccine. 156 people had received two doses and 50 people had received one dose. They exposed SARS-CoV-2 proteins in a virus model system to sera from vaccinated people and observed the antibody response, measuring how effectively antibodies prevented each variant from infecting cells (virus neutralization).

Release date: 02 December 2021
Source: EurekAlert

Probiotics improve nausea and vomiting in pregnancy - پروبیوتیک ها و بهبودی تهوع دوران بارداری

Findings also provide clues to why some people experience more stomach upset during pregnancy. In a first-of-its-kind study, researchers at the UC Davis School of Medicine found that probiotics significantly improve the symptoms of pregnancy-related nausea, vomiting and constipation. The findings were published in the journal Nutrients.

Nausea and vomiting affect about 85% of pregnancies and can significantly impact quality of life, particularly during early pregnancy.

Probiotics are thought to support the community of different microbes, often referred to as the “gut microbiome,” found in the gastrointestinal tract.

During pregnancy, hormones like estrogen and progesterone increase, bringing about many physical changes. These increases can also change the gut microbiome, which likely affects the digestive system functions and causes unwanted symptoms like nausea, vomiting and constipation.

The study lasted for 16 days. A total of 32 participants took a probiotic capsule twice a day for six days and then took two days off. They then repeated the cycle.

The probiotics were available over-the-counter and mainly contained Lactobacillus, a type of good bacteria. Each capsule contained approximately 10 billion live cultures at the time of manufacture.

Participants kept 17 daily observations of their symptoms during the duration of the study, for a total of 535 observations for the researchers to statistically assess.

What the researchers found was that taking the probiotic significantly reduced nausea and vomiting. Nausea hours (the number of hours participants felt nauseous) were reduced by 16%, and the number of times they vomited was reduced by 33%. Probiotic intake also significantly improved symptoms related to quality of life, such as fatigue, poor appetite and difficulty maintaining normal social activities, as scored by questionnaires.

Probiotics were also found to reduce constipation significantly.

Release date: 02 December 2021
Source: University of California – Davis Health 

The sunshine vitamin that Delivers on cardio health - نقش ویتامین دی در سلامت قلب

Free from the sun, vitamin D delivers a natural source for one of the hormones essential to our bodies, especially the bones. But when you’re down on this essential nutrient, it’s not only your bones that could suffer, but also your cardio health.

The study, which is published in European Heart Journal, shows that people with vitamin D deficiency are more likely to suffer from heart disease and higher blood pressure, than those with normal levels of vitamin D. For participants with the lowest concentrations the risk of heart disease was more than double that seen for those with sufficient concentrations.

Low concentrations of vitamin D are common in many parts of the world, with data from the UK Biobank showing that 55 per cent of participants have low levels of vitamin D (<50 nmol/L) and 13 per cent have severe deficiency (<25 nmol/L).

Low levels of vitamin D are recorded by an estimated 23 per cent of people in Australia, 24 per cent of people in the US, and 37 per cent of people in Canada.

Release date: 06 December 2021
Source: University of South Australia

Sunshine May Shield Children Young Adults from Multiple Sclerosis - ام اس و اثرات محافظتی آفتاب

Exposure to UV Rays Boost Vitamin D, May Protect Against Auto-Immune Disease. Living in sunny locations and spending time outdoors may raise the risk for skin cancer, but a new study led by UC San Francisco and the Australian National University shows that in children and young adults, sun exposure may protect against multiple sclerosis. The study follows previous work by other researchers that has demonstrated an association between increased ultraviolet exposure in childhood and lower odds of adult MS.

The study included 332 participants aged between 3 to 22, who had had MS for an average of seven months. Their locations and amount of sun exposure were matched by age and sex to 534 participants without MS, the researchers reported in their study, which publishes in the online issue of Neurology, the journal of the American Academy of Neurology.

In questionnaires filled in by participants with MS or their parents, 19 percent stated that they spent less than 30 minutes daily outdoors during the previous summer, compared to 6 percent of those who did not have MS. When the researchers adjusted for MS risks, like smoking and female sex, they found that the participants who spent an average of 30 minutes to one hour outdoors daily had a 52 percent lower chance of MS, compared to those who spent an average of less than 30 minutes outdoors daily.

Limited sun exposure and/or low levels of vitamin D have been associated with other conditions. These include Parkinson’s disease, Alzheimer’s and other types of dementia, as well as schizophrenia and other auto-immune diseases like Type 1 diabetes, Crohn’s disease and lupus.

Release date: 08 December 2021
Source: University of California – San Francisco

Coffee time Caffeine improves reaction to moving targets - تاثیر قهوه بر تمرکز

That morning coffee might be even more helpful than you think.

In the first study of its kind to explore caffeine’s effects on dynamic visual skills, researchers concluded that caffeine increases alertness and detection accuracy for moving targets. Caffeine also improved participants’ reaction times.

Visual acuity, also known as clarity of vision or sharpness of vision, refers to a person’s ability to detect and recognize small details and can be measured under static (stationary) or dynamic (moving) conditions. While both static and dynamic visual acuity provide important information about how we interact with the world around us, dynamic visual acuity skills are especially important in the many daily activities in which we, or objects around us are moving.

The study, Effects of caffeine ingestion on dynamic visual acuity, co-authored by Waterloo’s School of Optometry & Vision Science’s Dalton, and the University of Granada’s Redondo, Raimundo Jiménez, Rubén Molina and Jesús Vera, was published in the Journal of Psychopharmacology .

Release date: 01 December 2021
Source: University of Waterloo

Study links high cholesterol cardiovascular disease to plastics مواد پلاستیکی تهدیدکننده سلامت قلبی عروقی

Plastics, part of modern life, are useful but can pose a significant challenge to the environment and may also constitute a health concern. Indeed, exposure to plastic-associated chemicals, such as base chemical bisphenol A and phthalate plasticizers, can increase the risk of human cardiovascular disease. What underlying mechanisms cause this, however, remain elusive.

“We found dicyclohexyl phthalate, or DCHP, strongly binds to a receptor called pregnane X receptor, or PXR,” said Zhou, who is a professor in the UCR School of Medicine. “DCHP ‘turns on’ PXR in the gut, inducing the expression of key proteins required for cholesterol absorption and transport. Our experiments show that DCHP elicits high cholesterol by targeting intestinal PXR signaling.”

DCHP, a widely used phthalate plasticizer, has recently been proposed by the Environmental Protection Agency as a high-priority substance for risk evaluation. Not much is known yet about DCHP’s adverse effects in humans.

Zhou was joined in the research by Zhaojie Meng, Jinwei Liu, Rebecca Hernandez, and Miko Gonzales of UCR; and Yipeng Sui, Taesik Gwag, and Andrew J. Morris of the University of Kentucky. The study was published in Environmental Health Perspectives, a top journal in the environmental health field.

Release date: 30 November 2021
Source: University of California – Riverside

Rates of type 2 diabetes are higher in people with one of various common psychiatric disorders - شیوع بالاتر دیابت در اختلالات روانپزشکی

A new study published in Diabetologia (the journal of the European Association for the Study of Diabetes (EASD)) finds that the prevalence of type 2 diabetes (T2D) is elevated in people with a psychiatric disorder compared with the general population. The research was conducted by Nanna Lindekilde, Department of Psychology, University of Southern Denmark, Odense, Denmark, and colleagues.

Psychiatric disorders are common, impair the quality of life and are associated with increased mortality rates. This excess mortality is caused in part by more frequent suicides and accidents, but also by an elevated risk of developing physical conditions known to be linked to mental health problems such as cardiovascular and respiratory diseases. Diabetes is an increasingly common disease throughout the world and estimates suggest that 6% to 9% of the global general population are currently affected. Rates have been rising since 1990 onwards in a trend that is expected to continue for the next 20 years.

Release date: 29 November 2021
Source: Diabetologia

Telehealth-delivered diet and exercise program eased knee pain and triggered weight loss - تله مدیسین و درد زانو

New research investigating the benefits of telehealth-delivered exercise and diet programs has found 80 per cent of participants experienced improvement in knee pain and an average of 10 per cent in loss of body weight, with one man shedding 39 kilograms.

More than 400 individuals with knee osteoarthritis participated in the Better Knee, Better Me trial, developed by the University of Melbourne in partnership with Medibank and Austin Health.

Published in the Annals of Internal Medicine, the study shows researchers evaluated two six-month telehealth-delivered exercise programs, one with and one without a weight-loss dietary program, compared with an information-only control group.

During the trial, participants in the intervention groups were provided support from physiotherapists and dietitians via Zoom and a suite of resources. Those in the exercise plus diet group also received meal replacements so they could undertake a ketogenic low energy diet.

Compared to the group that only received information, both intervention programs resulted in benefits for pain, function and quality of life. Compared to the exercise-only program, the combined exercise and diet program led to additional benefits – including a greater reduction in pain, greater improvements in physical function, lower use of pain medications, and significant weight loss. After both programs, participants were also less willing to undergo knee joint replacement surgery.

Lead researcher and Director of the Centre for Health, Exercise and Sports Medicine at the University of Melbourne Professor Kim Bennell, said participants lost on average 10.2 kilograms over a six-month period with four out of five participants achieving significant improvement in pain. She said 30 per cent of participants lived in regional and rural Australia.

Release date: 30 November 2021
Source: University of Melbourne

extent of healthcare avoidance during COVID-19 - اجتناب بیماران از دریافت مشاوره پزشکی در زمان قرنطینه

One in five individuals avoided healthcare during lockdown in the COVID-19 pandemic, often for potentially urgent symptoms, according to a new study publishing in  PLOS Medicine by Silvan Licher of Erasmus University Medical Center Rotterdam, the Netherlands, and colleagues.

During the COVID-19 pandemic, consultations in both primary and specialist care declined compared to pre-pandemic levels. It is unclear to what extent healthcare avoidance by the general population contributed to these declines. In the new study, researchers sent out a paper questionnaire to 8,732 participants of the Rotterdam Study, a cohort study designed to investigate chronic diseases in mid to late-life, covering several COVID-19 related topics, including healthcare avoidance. 73% of participants responded between April and July 2020 and the final population for the study was 5,656 individuals residing in the same district in Rotterdam, the Netherlands.

About one in five (20.2%) of participants reported having avoided healthcare during the pandemic. Of those, 414 participants (36.3% of avoiders) reported symptoms that potentially warranted urgent medical attention, including limb weakness (13.6%), palpitations (10.8%) and chest pain (10.2%). However, there was no data available on the severity of symptoms. Groups most likely to have avoided healthcare included females (adjusted odds ratio (OR) 1.58, 95% confidence interval (CI) 1.38-1.82), those with poor self-appreciated health (per level decrease 2.00, 95% CI 1.80‑2.22), and those with high levels of depression (per point increase 1.13, 95% CI 1.11-1.14) and anxiety (per point increase 1.16, 95% CI 1.14-1.18). Lower educational level, older age, unemployment, smoking and concern about contracting COVID-19 were also associated with healthcare avoidance.

Release date: 23 November 2021
Source: EurekAlert 

Poor sleep linked to feeling older and worse outlook on ageing which can impact health - بدخوابی و احساس پیری

Poor sleep in the over 50s is linked to more negative perceptions of ageing, which in turn can impact physical, mental and cognitive health, new research has revealed.

A study led by the University of Exeter and found that people who rated their sleep the worst also felt older, and perceived their own physical and mental ageing more negatively.

Lead author Serena Sabatini, of the University of Exeter, said: “As we age, we all experience both positive and negative changes in many areas of our lives. However, some people perceive more negative changes than others. As we know that having a negative perception of ageing can be detrimental to future physical health, mental health, and cognitive health, an open question in ageing research is to understand what makes people more negative about ageing. Our research suggests that poor sleepers feel older, and have a more negative perception of their ageing. We need to study this further – one explanation could be that a more negative outlook influences both. However, it could be a sign that addressing sleep difficulties could promote a better perception of ageing, which could have other health benefits.”

Researchers surveyed 4,482 people aged 50 and over who are part of the PROTECT study. Run by the University of Exeter and the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London, and funded by the National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre, PROTECT is an innovative online study in which participants take regular cognitive tests and complete lifestyle questionnaires. The study aims to understand what helps people stay cognitively healthy in later life.

As a result of such comments, the team decided to conduct a questionnaire looking specifically at sleep. In the research, published in Behavioral Sleep Medicine, participants were asked whether they had experienced a list of negative age-related changes, such as poorer memory, less energy, increased dependence on the help of others, decreased motivation, and having to limit their activities. They also rated their quality of sleep. The participants completed both questionnaires twice, one year apart.

Release date: 22 November 2021
Source: University of Exeter