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Insomnia disrupted sleep and burnout linked to higher odds of severe COVID19 - اهمیت خواب در زمان همه گیری کرونا

Each 1-hour increase in sleep associated with 12% lower odds of infection among clinicians

Insomnia, disrupted sleep, and daily burnout are linked to a heightened risk of not only becoming infected with coronavirus, but also having more severe disease and a longer recovery period, suggests an international study of healthcare workers, published in the online journal BMJ Nutrition, Prevention & Health.

Every 1-hour increase in the amount of time spent asleep at night was associated with 12% lower odds of becoming infected with COVID-19, the findings indicate.

Disrupted/insufficient sleep and work burnout have been linked to a heightened risk of viral and bacterial infections, but it’s not clear if these are also risk factors for COVID-19, say the researchers.

To explore this further, they drew on the responses to an online survey for healthcare workers repeatedly exposed to patients with COVID-19 infection, such as those working in emergency or intensive care, and so at heightened risk of becoming infected themselves.

Release date: 23 March 2021
Source: BMJ

high vitamin D levels may protect against COVID-19 especially for Black people - نقش محافظتی ویتامین D در برابر کرونا

A new research study at the University of Chicago Medicine has found that when it comes to COVID-19, having vitamin D levels above those traditionally considered sufficient may lower the risk of infection, especially for Black people.

The study, published in JAMA Open Network on March 19, retrospectively examined the relationship between vitamin D levels and likelihood of testing positive for COVID-19. While levels of 30 ng/ml or more are usually considered sufficient, the authors found that Black individuals who had levels of 30 to 40 ng/ml had a 2.64 times higher risk of testing positive for COVID-19 than people with levels of 40 ng/ml or greater. Statistically significant associations of vitamin D levels with COVID-19 risk were not found in white people. The study looked at data from more than 3,000 patients at UChicago Medicine who had had their vitamin D levels tested within 14 days before a COVID-19 test.

Release date: 19 March 2021
Source: University of Chicago Medical Center

Covid-19 risk increases with airborne pollen - ریزگردها و خطر انتقال کرونا

When airborne pollen levels are higher, increased SARS-CoV-2 infection rates can be observed. These results were determined by a large-scale study conducted by an international team headed by researchers at the Technical University of Munich (TUM) and the Helmholtz Zentrum München. Members of high-risk groups could protect themselves by watching pollen forecasts and wearing dust filter masks.

In the spring of 2020, the outbreak of the coronavirus pandemic appeared to coincide with the tree pollen season in the northern hemisphere. These observations prompted an international team of researchers to conduct an extensive investigation: The scientists wanted to know whether there is a demonstrable link between airborne pollen concentrations and SARS-CoV-2 infection rates. Proceedings of the National Academy of Sciences

Release date: 08 March 2021
Source: Technical University of Munich (TUM)

Intellectual Disabilities are at Greatest Risk of Death from COVID19 - ناتوانی ذهنی فاکتورخطر مهم برای کووید19

Intellectual disability puts individuals at higher risk of dying earlier in life than the general population, for a variety of medical and institutional reasons. A new study from Jefferson Health examined how the COVID-19 pandemic has affected this group, which makes up 1-3% of the US population. The study, published in the New England Journal of Medicine (NEJM) Catalyst, found that intellectual disability was second only to older age as a risk factor for dying from COVID-19.

Release date: 05 March 2021
Source: Thomas Jefferson University

Aspirin and COVID19 - اثرات ضدکرونایی آسپرین

New study finds aspirin use for cardiovascular disease may reduce likelihood of infection of COVID-19.

Aspirin is an established, safe, and low-cost medication in long-standing common use in prevention and treatment of cardiovascular diseases, and in the past a pain relief and fever reducing medication. The use of aspirin was very popular during the 1918 Spanish Influenza pandemic, several decades before in-vitro confirmation of its activity against RNA viruses. Studies showed that aspirin, in addition to its well-known anti-inflammatory effects, could modulate the innate and adaptive immune responses helping the human immune system battle some viral infections.

With this information in mind Israeli researchers hypothesized that pre-infection treatment with low-dose aspirin (75mg) use might have a potential beneficial effect on COVID-19 susceptibility and disease duration. A joint team from Leumit Health Services, Bar-Ilan University, and Barzilai Medical Center conducted an observational epidemiological study, utilizing data from Leumit Health Services, a national health maintenance organization in Israel. Their findings were recently published in The FEBS Journal.

Release date: 11 March 2021
Source: Bar-Ilan University

depression and anxietyin health care workers during the COVID-19 pandemic - میزان بالای اختلالات روانی در کادر درمان به دنبال همه گیری کرونا

The COVID-19 pandemic has placed health care workers under psychological stress. Previous reviews show a high prevalence of mental disorders among health care workers, but these need updating and inclusion of studies written in Chinese. The aim of this systematic review and meta-analysis was to provide updated prevalence estimates for depression, anxiety and post-traumatic stress disorder (PTSD) among health care workers during the COVID-19 pandemic.

Data on the prevalence of moderate depression, anxiety and PTSD was pooled across 65 studies involving 97,333 health care workers across 21 countries. The pooled prevalence of depression was 21.7% (95% CI, 18.3%-25.2%), of anxiety 22.1% (95% CI, 18.2%-26.3%), and of PTSD 21.5% (95% CI, 10.5%-34.9%). Prevalence estimates are also provided for a mild classification of each disorder. Pooled prevalence estimates of depression and anxiety were highest in studies conducted in the Middle-East (34.6%; 28.9%). Subgroup and meta-regression analyses were conducted across covariates, including sampling method and outcome measure. PLOS ONE

Release date: 10 March 2021
Source: PLOS

New evidence COVID-19 antibodies, vaccines less effective against variants - تاثیر کمتر واکسیناسیون علیه کروناویروس جدید

New research at Washington University School of Medicine in St. Louis indicates that three new, fast-spreading variants of the virus that cause COVID-19 can evade antibodies that work against the original form of the virus that sparked the pandemic. With few exceptions, whether such antibodies were produced in response to vaccination or natural infection, or were purified antibodies intended for use as drugs, the researchers found more antibody is needed to neutralize the new variants.

The findings, from laboratory-based experiments and published March 4 in Nature Medicine, suggest that COVID-19 drugs and vaccines developed thus far may become less effective as the new variants become dominant, as experts say they inevitably will. The researchers looked at variants from South Africa, the United Kingdom and Brazil. Nature Medicine

Release date: 04 March 2021
Source: Washington University School of Medicine

Statin Use Associated With Increased Survival in Severe COVID19 - داروهای استاتین کاهنده مرگ در بیماران کرونایی

People who took statins to lower cholesterol were approximately 50% less likely to die if hospitalized for COVID-19.

Study analyzed data from electronic health records

Based on their observations, the authors looked at outcomes for 2,626 patients with COVID-19 who were admitted to a quaternary academic medical center in Manhattan during the first 18 weeks of the pandemic.

The researchers compared 648 patients who regularly used statins before developing COVID-19 to 648 patients who did not use statins. Patients in each group were matched so that there were no significant differences in demographics, comorbidities, or use of other medications at home. Nature Communications 

Release date: 26 February 2021
Source: Columbia University Irving Medical Center

COVID-19 can kill heart muscle cells interfere with contraction - تاثیر مخرب کرونا بر قلب

Study reveals details of how coronavirus infects heart; models of tissue damage may help develop potential therapies.

Since early in the pandemic, COVID-19 has been associated with heart problems, including reduced ability to pump blood and abnormal heart rhythms. But it’s been an open question whether these problems are caused by the virus infecting the heart, or an inflammatory response to viral infection elsewhere in the body. Such details have implications for understanding how best to treat coronavirus infections that affect the heart.

A new study from Washington University School of Medicine in St. Louis provides evidence that COVID-19 patients’ heart damage is caused by the virus invading and replicating inside heart muscle cells, leading to cell death and interfering with heart muscle contraction. The researchers used stem cells to engineer heart tissue that models the human infection and could help in studying the disease and developing possible therapies.

Release date: 01 March 2021
Source: Washington University School of Medicine

Prioritizing oldest for COVID-19 vaccines saves more lives years of life - سالمندان باید در اولویت تزریق واکسن کرونا باشند

Challenging the idea that older people with shorter life expectancies should rank lower in coronavirus immunization efforts, new UC Berkeley research shows that giving vaccine priority to those most at risk of dying from COVID-19 will save the maximum number of lives, and their potential or future years of life. Since older age is accompanied by falling life expectancy, it is widely assumed that means we’re saving fewer years of life.

The findings, published in the journal Proceedings of the National Academy of Sciences.

Release date: 25 February 2021
Source: University of California – Berkeley