Tag Archive for: MS

Milk may exacerbate MS symptoms

Milk may exacerbate MS symptoms - شیر و بیماری ام اس

Study by the University of Bonn: Cow’s milk protein triggers autoimmune response in mice that damages neurons
Multiple sclerosis sufferers often complain of more severe disease symptoms after consuming dairy products. Researchers at the Universities of Bonn and Erlangen-Nuremberg have now found a possible cause for this. According to the study, a protein in cow’s milk can trigger inflammation that targets the “insulating layer” around nerve cells. The study was able to demonstrate this link in mice, but also found evidence of a similar mechanism in humans. The researchers therefore recommend that certain groups of sufferers avoid dairy products. The study has now been published in the journal PNAS(Proceedings of the National Academy of Sciences).

Release date: 01 March 2022
Source: University of Bonn

Epstein-Barr virus may be leading cause of multiple sclerosis

Epstein Barr virus may be leading cause of multiple sclerosis - ویروس اپشتین بار و ام اس

Multiple sclerosis (MS), a progressive disease that affects 2.8 million people worldwide and for which there is no definitive cure, is likely caused by infection with the Epstein-Barr virus (EBV), according to a study led by Harvard T.H. Chan School of Public Health researchers.

Their findings were published online in Science.

“The hypothesis that EBV causes MS has been investigated by our group and others for several years, but this is the first study providing compelling evidence of causality,” said Alberto Ascherio, professor of epidemiology and nutrition at Harvard Chan School and senior author of the study. “This is a big step because it suggests that most MS cases could be prevented by stopping EBV infection, and that targeting EBV could lead to the discovery of a cure for MS.”

MS is a chronic inflammatory disease of the central nervous system that attacks the myelin sheaths protecting neurons in the brain and spinal cord. Its cause is not known, yet one of the top suspects is EBV, a herpes virus that can cause infectious mononucleosis and establishes a latent, lifelong infection of the host. Establishing a causal relationship between the virus and the disease has been difficult because EBV infects approximately 95% of adults, MS is a relatively rare disease, and the onset of MS symptoms begins about 10 years after EBV infection. To determine the connection between EBV and MS, the researchers conducted a study among more than 10 million young adults on active duty in the U.S. military and identified 955 who were diagnosed with MS during their period of service.

Release date: 13 January 2022
Source: Harvard T.H. Chan School of Public Health

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Probiotics improve nausea and vomiting in pregnancy

Probiotics improve nausea and vomiting in pregnancy - پروبیوتیک ها و بهبودی تهوع دوران بارداری

Findings also provide clues to why some people experience more stomach upset during pregnancy. In a first-of-its-kind study, researchers at the UC Davis School of Medicine found that probiotics significantly improve the symptoms of pregnancy-related nausea, vomiting and constipation. The findings were published in the journal Nutrients.

Nausea and vomiting affect about 85% of pregnancies and can significantly impact quality of life, particularly during early pregnancy.

Probiotics are thought to support the community of different microbes, often referred to as the “gut microbiome,” found in the gastrointestinal tract.

During pregnancy, hormones like estrogen and progesterone increase, bringing about many physical changes. These increases can also change the gut microbiome, which likely affects the digestive system functions and causes unwanted symptoms like nausea, vomiting and constipation.

The study lasted for 16 days. A total of 32 participants took a probiotic capsule twice a day for six days and then took two days off. They then repeated the cycle.

The probiotics were available over-the-counter and mainly contained Lactobacillus, a type of good bacteria. Each capsule contained approximately 10 billion live cultures at the time of manufacture.

Participants kept 17 daily observations of their symptoms during the duration of the study, for a total of 535 observations for the researchers to statistically assess.

What the researchers found was that taking the probiotic significantly reduced nausea and vomiting. Nausea hours (the number of hours participants felt nauseous) were reduced by 16%, and the number of times they vomited was reduced by 33%. Probiotic intake also significantly improved symptoms related to quality of life, such as fatigue, poor appetite and difficulty maintaining normal social activities, as scored by questionnaires.

Probiotics were also found to reduce constipation significantly.

Release date: 02 December 2021
Source: University of California – Davis Health 

Sunshine May Shield Children, Young Adults from Multiple Sclerosis

Sunshine May Shield Children Young Adults from Multiple Sclerosis - ام اس و اثرات محافظتی آفتاب

Exposure to UV Rays Boost Vitamin D, May Protect Against Auto-Immune Disease. Living in sunny locations and spending time outdoors may raise the risk for skin cancer, but a new study led by UC San Francisco and the Australian National University shows that in children and young adults, sun exposure may protect against multiple sclerosis. The study follows previous work by other researchers that has demonstrated an association between increased ultraviolet exposure in childhood and lower odds of adult MS.

The study included 332 participants aged between 3 to 22, who had had MS for an average of seven months. Their locations and amount of sun exposure were matched by age and sex to 534 participants without MS, the researchers reported in their study, which publishes in the online issue of Neurology, the journal of the American Academy of Neurology.

In questionnaires filled in by participants with MS or their parents, 19 percent stated that they spent less than 30 minutes daily outdoors during the previous summer, compared to 6 percent of those who did not have MS. When the researchers adjusted for MS risks, like smoking and female sex, they found that the participants who spent an average of 30 minutes to one hour outdoors daily had a 52 percent lower chance of MS, compared to those who spent an average of less than 30 minutes outdoors daily.

Limited sun exposure and/or low levels of vitamin D have been associated with other conditions. These include Parkinson’s disease, Alzheimer’s and other types of dementia, as well as schizophrenia and other auto-immune diseases like Type 1 diabetes, Crohn’s disease and lupus.

Release date: 08 December 2021
Source: University of California – San Francisco

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Vibration Training for Multiple Sclerosis

Vibration Training for Multiple Sclerosis - تمرینات ویبراسیون موثر در بیماران ام اس

Multiple sclerosis (MS) is a chronic neurological disease that affects the body’s central nervous system. It can limit a person’s mobility, impair physical and cognitive functions, and increase the risk of falling, collectively compromising quality of life.

Cognitive impairment has been particularly difficult for researchers to address, with few intervention strategies proven effective in preserving or restoring cognitive functions for people with MS.

Associate Professor Feng Yang worked with Francois Bethoux from the Cleveland Clinic Foundation and Georgia State University faculty members Pey-Shan Wen and Yichuan Zhao to study whether vibration training – an intervention used to improve physical function for people with MS – could also improve cognitive function and overall quality of life.

Vibration training requires individuals to sit or stand on a platform that vibrates at a fast pace but with a small movement for a specific amount of time.

For Yang’s study, believed to be the first of its kind, 18 adults with MS completed assessments to determine their perceived disability status, cognitive function and quality of life. Then, some of the participants attended vibration training three times a week for six weeks.

The study, published in the International Journal of MS Care, found that the vibration training improved not only physical abilities, such as increased walking speeds, but also cognitive functions, such as memory capacity and executive function.

Release date: 28 October 2021
Source: Georgia State University

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A plant-based diet combined with a healthy microbiome may protect against multiple sclerosis

A plant based diet combined with a healthy microbiome may protect against multiple sclerosis - تغذیه و ام اس

The study shows that a diet rich in isoflavone, a phytoestrogen or plant-based compound that resembles estrogen, protects against multiple sclerosis-like symptoms in a mouse model of the disease. Importantly, the isoflavone diet was only protective when the mice had gut microbes capable of breaking down the isoflavones. The findings were published in Science Advances.

A new University of Iowa study suggests that metabolism of plant-based dietary substances by specific gut bacteria, which are lacking in patients with multiple sclerosis (MS), may provide protection against the disease.

Isoflavones are found in soybeans, peanuts, chickpeas and other legumes. The study also found that mice fed the isoflavone diet have a microbiome that is similar to the microbiome found in healthy people and includes the bacteria which can metabolize isoflavones. Conversely, a diet lacking isoflavones promotes a microbiome in mice which is similar to one observed in patients with MS and lacks beneficial bacteria that can metabolize isoflavone.

Release date: 12 July 2021
Source: University of Iowa Health Care

In many cases, multiple sclerosis starts long before the diagnosis

In many cases multiple sclerosis starts long before the diagnosis - ام اس تشخیصی تاخیری

Years before they are diagnosed, persons with multiple sclerosis (MS) make significantly more visits to doctors and hospitals than others. Specialists have recently discussed whether this might represent a preliminary phase of MS – known as a prodrome. A research team at the Technical University of Munich (TUM) has now published results of a study suggesting that, in many cases, the complaints may relate to unrecognized early clinical MS events.

Persons suffering from the autoimmune disease multiple sclerosis can develop various neurological symptoms caused by damage to the nervous system. Especially in early stages, these may include sensory dysfunction such as numbness or visual disturbances. In most patients, MS starts with recurring episodes of neurological disability, called relapses or demyelinating events. These clinical events are followed by a partial or complete remission. Especially in the beginning, the symptoms vary widely, so that it is often difficult even for experienced doctors to interpret them correctly to arrive at a diagnosis of MS. Neurology

Release date: 21 Jun 2021
Source: Technical University of Munich (TUM)

Moms with MS at no more risk of pregnancy complications than moms without MS

Moms with MS at no more risk of pregnancy complications than moms without MS - ام اس و بارداری

Women with multiple sclerosis (MS) may not be at a higher risk of pregnancy complications like gestational diabetes, emergency cesarean section or stillbirth than women who do not have the disease, according to a study in the February 3, 2021, online issue issue of Neurology® Clinical Practice, an official journal of the American Academy of Neurology. However, the study did find that babies born to mothers with MS had a higher chance of being delivered by elective cesarean section (c-section) or induced delivery, and being small for their age compared to babies of women who did not have the disease.

Researchers found no difference in risk of several pregnancy complications between women with MS and women without it. No differences were found in risk of preeclampsia, gestational diabetes, placenta complications, emergency c-section, instrumental delivery, stillbirth, preterm birth, congenital malformations or low Apgar score. Apgar score is a test of a newborn’s health, including measures like heart rate, reflexes and muscle tone immediately after birth.

Release date: 03 February 2021
Source: American Academy of Neurology

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Mechanisms identified to restore myelin sheaths after injury or in multiple sclerosis

Mechanisms identified to restore myelin sheaths after injury or in multiple sclerosis - امیدهای تازه برای درمان ام اس با کنترل ترمیم غلاف میلین

Researchers reveal a potential method for treating multiple sclerosis / Theophylline activates histone deacetylase, enabling the reconstruction of myelin sheaths.

A research team led by neurobiologist Professor Claire Jacob has identified an important mechanism that can be used to control the restoration of myelin sheaths following traumatic injury and in degenerative diseases. With the insights gained, the researchers were able to regenerate damaged myelin sheaths in mice by treating them with the active substance theophylline, thereby restoring their nerve cell function. The groundbreaking findings are the result of research carried out at Johannes Gutenberg University Mainz (JGU) and the University of Fribourg in Switzerland.

Release date: 24 August 2020

Source: Johannes Gutenberg Universitaet Mainz

New hope for MS Treatment

treatment Multiple Sclerosis (MS) - درمان ام اس

New study led by Charité – Universitätsmedizin Berlin uncovers how the body initiates repair mechanisms which will limit the extent of any damage to myelin sheath. This study, published in Nature Communications, may open the door to a new way for Multiple Sclerosis (MS) treatment.