Tag Archive for: osteoarthritis

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Does physical activity impact risk of knee osteoarthritis?

Does physical activity impact risk of knee osteoarthritis - آیا فعالیت شدید آرتروز ایجاد می کند

In an analysis published in Arthritis & Rheumatology, investigators did not find any link between the amount and duration of physical activity with individuals’ risk of developing knee osteoarthritis.

The analysis included six global community-based studies including a total of 5,065 participants with and without knee osteoarthritis who were followed for five to 12 years.

“Knowing that the amount of physical activity and time spent doing it is not associated with the development of knee osteoarthritis is important evidence for both clinicians and the public who may need to consider this when prescribing physical activity for health,” said co–lead author Thomas Perry, BSc, PhD, of the University of Oxford, in the UK.

Next, it will be important to understand the role of injury and specific types of activity within this association, noted co–lead author Lucy S. Gates, PhD, of the University of Southampton, and co–senior author Maria Sanchez-Santos, of the University of Oxford.

Release date: 03 November 2021
Source: Wiley

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Nasal cartilage relieves osteoarthritis in the knee

Nasal cartilage relieves osteoarthritis in the knee - درمان جدید و جالب آرتروز

Cartilage cells from the nasal septum can not only help repair cartilage injuries in the knee – according to researchers from the University of Basel and the University Hospital Basel, they can also withstand the chronic inflammatory tissue environment in osteoarthritis and even counteract the inflammation.

A research team at the Department of Biomedicine of the University of Basel and the University Hospital of Basel is cultivating cartilage tissue from cells of the nasal septum to repair articular cartilage in the knee. The team led by Professor Ivan Martin and Professor Andrea Barbero has already succeeded in doing this in initial clinical studies on isolated cartilage damage, and they have now reported that the approach could also be suitable for degenerative joint diseases such as osteoarthritis. Their findings have been published in the journal Science Translational Medicine.

Osteoarthritis is associated with cartilage degradation, which can cause severe pain and reduce mobility. The therapeutic approach up to now aims at palliative treatment of the inflammation and pain until a knee joint replacement by a prosthetic implant becomes unavoidable. Joint prostheses, however, have a limited durability, which makes the treatment problematic, especially in younger patients.

Release date: 01 September 2021
Source: University of Basel

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New Approach to Treating Osteoarthritis Advances

New Approach to Treating Osteoarthritis Advances - پیشرفت های جدید در درمان آرتروز

Injections of a natural “energy” molecule prompted regrowth of almost half of the cartilage lost with aging in knees, a new study in rodents shows.

The study results revolve around the long-established idea that machines within animal and human cells turn the sugars, fats, and proteins we eat into energy used by the body’s millions of cells. The molecule most used to store that energy is called adenosine triphosphate, or ATP. Along with this central role in metabolism, adenosine also helps signal other cells and serves as a building block of genetic material, and so is central to the growth of human tissue.

Previous research had shown that maintaining supplies of adenosine, known to nourish the chondrocyte cells that make cartilage, also prevented osteoarthritis in similar animal models of the disease.

Published online in the journal Scientific Reports on August 10, the study rodents received 8 weekly injections of adenosine, which prompted regrowth rates of cartilage tissue between 50 percent and 35 percent as measured by standard laboratory scores.

Release date: 10 August 2020

Source: NYU Langone Health / NYU School of Medicine

Nutrition in osteoarthritis

Researchers found a possible association between diet and pain relief for patients with osteoarthritis, according to study published in Rheumatology journal.

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Tag Archive for: osteoarthritis

Osteoarthritis

  • Osteoarthritis

Definition:


Osteoarthritis, also known as “degenerative joint disease,” is considered a non-inflammatory type of arthritis affecting primarily the cartilage

Osteoarthritis is common


  • Osteoarthritis is the most common form of arthritis. It causes more work disability in the United States than any other disease.
  • Arthritis affects 20% of Americans, about half of whom primarily have OA.
  • DJD is found radiographically in almost all 75-year-old patients, most of whom are asymptomatic.

Classification


Primary(idiopathic)

  • Generalized OA: Involves five or more joints, most often
    • DIP joints of the hand (Herberden nodes)
    • PIP joints of the hand (Bouchard nodes)
    • First carpometacarpal joint
    • First MTP joint of the feet
    • Knee
    • Hip
    • Spine
  • Large-joint OA: Might occur as part of generalized OA or alone.
    • Knees
    • OA
  • Erosive OA: Rare

Hereditary (resulting from collagen gene defects)

Secondary: Results from previous cartilage damage.

  • Episodic trauma
  • Congenital anatomic abnormalities (slipped capital femoral epiphyses, congenital hip dysplasias)
  • Neuropathies
  • Endocrine & Metabolic causes (obesity, hemochromatosis, Wilson disease, CPPD disease, Paget disease, acromegaly)



Clinical Findings


Most OA is asymptomatic.

Symptomatic OA is characterized by

  • Local pain of gradual onset exacerbated by using the involved joint. Pain typically worsens as the day progresses and is relieved by rest

Treatment Options


Non-pharmacologic Therapy

  • Patient education and self-management programs including rest during pain, avoidance of trauma, etc.
  • Weight loss
  • Physical and occupational therapy
  • ROM and strengthening exercises
  • Aerobic conditioning especially swimming and walking
  • Assistive devices for ambulation and activities of daily living (canes, walkers, bathtub, toilet wall bars, etc.)
  • Acupuncture

Pharmacologic Therapy

  • Oral non-opioid analgesics (acetaminophen)
  • Topical analgesics (capsaicin cream)
  • NSAIDs (Naproxen, Ibuprofen, Diclofenac, Indomethacin, Piroxicam)
  • CoX2 inhibitors (Celecoxib)
  • Intra-articular injections: Steroid, Platelet Rich Plasma (PRP), Hyaluronate, Ozone
  • Opioid analgesics (e.g., Tramadol)

Surgical Therapy

  • Closed tidal joint lavage
  • Arthroscopic debridement and joint lavage
  • Osteotomy
  • Total joint arthroplasty



Recent Studies Show


  • Some foods can fight osteoarthritis (Details)