Via drug repositioning, Osaka City University creates combination of rifampicin and resveratrol and have shown in mouse models that the nasal administration improves cognitive function without the negative liver side effects of rifampicin alone.

Researchers from Osaka City University have shown in mice models of Alzheimer’s disease, frontotemporal dementia, and dementia with Lewy bodies, that the intranasal administration of rifampicin and resveratrol in combination is safer and improves cognitive function more than rifampicin alone. The research results are expected to lead to the development of safe and effective nasal spray for the prevention of dementia.

The results of this study were published online in the Swiss scientific journal Frontiers in Neuroscience.

Release date: 28 December 2021
Source: Osaka City University