Neurologic disorders Archives - Page 2 of 10 - Dr Amin Azhari

Physical activity may protect your brain as you age

Even just a few more steps a day benefits cognitive function

We all know we should exercise and eat healthy. But doing that isn’t just good for maintaining your figure as you age.

New research from the University of Georgia shows that physical activity could help protect your cognitive abilities as you age. And it doesn’t have to be intense exercise to make an impact.

Exercise improves brain function
Published in Sport Sciences for Health, the study followed 51 older adults, tracking their physical activity and fitness measurements. The participants performed tests specifically designed to measure cognitive functioning and underwent MRIs to assess brain functioning.

They also wore a device that measured the intensity of the wearer’s physical activity, number of steps taken and distance covered. The researchers assessed fitness through a six-minute walking test, during which participants walked as quickly as they could to cover the most distance possible within the time limit.

Release date: 08 March 2022
Source: University of Georgia

LEAD EXPOSURE IN LAST CENTURY SHRANK IQ SCORES OF HALF OF AMERICANS

In 1923, lead was first added to gasoline to help keep car engines healthy. However, automotive health came at the great expense of our own well-being.

A new study calculates that exposure to car exhaust from leaded gas during childhood stole a collective 824 million IQ points from more than 170 million Americans alive today, about half the population of the United States.

The findings, from Aaron Reuben, a PhD candidate in clinical psychology at Duke University, and colleagues at Florida State University, suggest that Americans born before 1996 may now be at greater risk for lead-related health problems, such as faster aging of the brain. Leaded gas for cars was banned in the U.S. in 1996, but the researchers say that anyone born before the end of that era, and especially those at the peak of its use in the 1960s and 1970s, had concerningly high lead exposures as children.

The team’s paper appeared the week of March 7 in the journal Proceedings of the National Academy of Sciences.

Lead is neurotoxic and can erode brain cells after it enters the body. As such, there is no safe level of exposure at any point in life, health experts say. Young children are especially vulnerable to lead’s ability to impair brain development and lower cognitive ability. Unfortunately, no matter what age, our brains are ill-equipped for keeping it at bay.

Release date: 07 March 2022
Source: Duke University

One alcoholic drink a day linked with reduced brain size

The research, using a dataset of more than 36,000 adults, revealed that going from one to two drinks a day was associated with changes in the brain equivalent to aging two years. Heavier drinking was linked with an even greater toll.

The science on heavy drinking and the brain is clear: The two don’t have a healthy relationship. People who drink heavily have alterations in brain structure and size that are associated with cognitive impairments.

But according to a new study, alcohol consumption even at levels most would consider modest—a few beers or glasses of wine a week—may also carry risks to the brain. An analysis of data from more than 36,000 adults, led by a team from the University of Pennsylvania, found that light-to-moderate alcohol consumption was associated with reductions in overall brain volume.

The link grew stronger the greater the level of alcohol consumption, the researchers showed. As an example, in 50-year-olds, as average drinking among individuals increases from one alcohol unit (about half a beer) a day to two units (a pint of beer or a glass of wine) there are associated changes in the brain equivalent to aging two years. Going from two to three alcohol units at the same age was like aging three and a half years. The team reported their findings in the journal Nature Communications.

Release date: 04 March 2022
Source: University of Pennsylvania

Higher education and language skills may help ward off dementia

New research has found that people with mild cognitive impairment may not inevitably develop dementia and, in fact, having higher education and advanced language skills more than doubles their chances of returning to normal.

The study, led by researchers at the University of Waterloo, may reassure those with mild cognitive impairment as it contradicts a common assumption that the condition is simply an early stage of dementia. People with mild cognitive impairment show signs of cognitive decline, but not enough to prevent them from performing typical daily tasks. They have been considered at higher risk of progressing to the more severe cognitive decline seen in dementia.

The study also found that language skills, whether reflected in high grades in English in school or in strong writing that was grammatically complex and full of ideas, were also protective.

The researchers discovered that almost one-third of 472 women diagnosed with mild cognitive impairment reverted to normal cognition at least once over an average of eight-and-a-half years following their diagnosis, with more than 80 per cent of them never developing dementia.

Almost another third of the total number progressed to dementia without ever reverting to normal cognition, while three per cent stayed in the mild cognitive impairment stage, and 36 per cent died. None of the participants reverted from dementia to mild cognitive impairment.

The researchers also highlighted that reverse transitions are much more common than progressing to dementia in relatively younger individuals who didn’t carry a certain genetic risk factor and had high levels of education and language skills.

Release date: 03 March 2022
Source: University of Waterloo

Covid-19

Milk may exacerbate MS symptoms

Study by the University of Bonn: Cow’s milk protein triggers autoimmune response in mice that damages neurons
Multiple sclerosis sufferers often complain of more severe disease symptoms after consuming dairy products. Researchers at the Universities of Bonn and Erlangen-Nuremberg have now found a possible cause for this. According to the study, a protein in cow’s milk can trigger inflammation that targets the “insulating layer” around nerve cells. The study was able to demonstrate this link in mice, but also found evidence of a similar mechanism in humans. The researchers therefore recommend that certain groups of sufferers avoid dairy products. The study has now been published in the journal PNAS(Proceedings of the National Academy of Sciences).

Release date: 01 March 2022
Source: University of Bonn

Nutrition in rehabilitation

A High-Fiber Diet May Reduce Risk of Dementia

We’re always hearing that we should eat more fiber. It’s known to be vitally important for a healthy digestive system and also has cardiovascular benefits like reduced cholesterol. Now, evidence is emerging that fiber is also important for a healthy brain. In a new study published this month in the journal Nutritional Neuroscience, researchers in Japan have shown that a high-fiber diet is associated with a reduced risk of developing dementia.

“Dementia is a devastating disease that usually requires long-term care,” says lead author of the study Professor Kazumasa Yamagishi. “We were interested in some recent research which suggested that dietary fiber may play a preventative role. We investigated this using data that were collected from thousands of adults in Japan for a large study that started in the 1980s.”

Participants completed surveys that assessed their dietary intake between 1985 and 1999. They were generally healthy and aged between 40 and 64 years. They were then followed up from 1999 until 2020, and it was noted whether they developed dementia that required care.

The researchers split the data, from a total of 3739 adults, into four groups according to the amount of fiber in their diets. They found that the groups who ate higher levels of fiber had a lower risk of developing dementia.

The team also examined whether there were differences for the two main types of fiber: soluble and insoluble fibers. Soluble fibers, found in foods such as oats and legumes, are important for the beneficial bacteria that live in the gut as well as providing other health benefits. Insoluble fibers, found in whole grains, vegetables, and some other foods, are known to be important for bowel health. The researchers found that the link between fiber intake and dementia was more pronounced for soluble fibers.

The team has some ideas as to what might underlie the link between dietary fiber and the risk of dementia.

Release date: 10 February 2022
Source: University of Tsukuba

Public Health, Public Health, Public Health, Public Health, Public Health, Public Health, Public Health, Public Health

Heart attack survivors may be less likely to develop Parkinson’s disease

Research Highlights:

People who have had a heart attack are at increased risk of stroke and vascular dementia; however, a new study found they may be less likely to develop Parkinson’s disease.
A large, nationwide study in Denmark found that the risk of Parkinson’s disease was moderately lower among people who have had a heart attack than among the general population.

People who have had a heart attack may be slightly less likely than people in the general population to develop Parkinson’s disease later in life, according to new research published today in the Journal of the American Heart Association, an open access, peer-reviewed Journal of the American Heart Association.

Parkinson’s disease is a brain disorder characterized by progressive loss of physical movement, including tremors, slow or slurred speech, and/or stiffness or limited range of motion for walking and other physical activities. There is no cure for Parkinson’s disease, and it is also associated with behavioral changes, depression, memory loss and fatigue. Secondary parkinsonism, which has symptoms similar to Parkinson’s disease, may be caused by stroke, psychiatric or cardiovascular medications, or other illness.

The researchers examined health registries from the Danish National Health Service. They compared the risk of Parkinson’s disease and secondary parkinsonism among about 182,000 patients who had a first-time heart attack between 1995 and 2016 (average age 71 years old; 62% male) and more than 909,000 controls matched for age, sex and year of heart attack diagnosis. The results were adjusted for a variety of factors known to influence the risk of either heart attack or Parkinson’s disease.

Release date: 16 February 2022
Source: American Heart Association

Simpler and reliable ALS diagnosis with blood tests

Blood tests may enable more accurate diagnosis of ALS at an earlier stage of the disease. As described in a study by researchers at University of Gothenburg and Umeå University, it involves measuring the blood level of a substance that, as they have also shown, varies in concentration depending on which variant of ALS the patient has.

Currently, it is difficult to diagnose amyotrophic lateral sclerosis (ALS), the most common form of motor neuron disease, early in the course of the disease. Even after a prolonged investigation, there is a risk of misdiagnosis due to other diseases that may resemble ALS in early stages. Much would be gained from earlier correct diagnosis and, according to the researchers, the current findings look promising.

Neurofilaments — proteins with a special role in the cells and fibers of nerves — are the substances of interest. When the nervous system is damaged, neurofilaments leak into the cerebrospinal fluid (CSF) and in lower concetrations in blood compared to CSF. In their study, scientists at Umeå University and the University Hospital of Umeå, as well as at the University of Gothenburg and Sahlgrenska University Hospital in Gothenburg, demonstrated that CSF and blood levels of neurofilaments can differentiate ALS from other diseases that may resemble early ALS.

The study, published in Scientific Reports.

Release date: 26 January 2022
Source: University of Gothenburg

Nutrition in rehabilitation, Nutrition in rehabilitation

Meat, Multiple Sclerosis, and the Microbiome

Studying the connections between meat, gut bacteria, and autoimmune attacks on the nervous system. Eating more meat, having less of certain bacteria in the gut, and more of certain immune cells in the blood, all link with multiple sclerosis, reports a team of researchers led by UConn Health and the Washington University School of Medicine. The work, published in issue of EBioMedicine, teased out subtle connections that could lead to a better understanding of the causes of the disease.

Multiple sclerosis (MS) is an autoimmune disease affecting fewer than 3 million people worldwide but costing $28 billion annually in the US alone—and untold suffering. MS is more prevalent in specific regions, particularly the northern mid-latitudes, suggesting that geography is somehow linked to the disease, perhaps involving diet. But teasing out the exact relationships between diet, immune response, and MS has been difficult. MS is most obviously an autoimmune disease in which the body attacks the insulation surrounding its nerves. When the insulation is damaged enough, the nerves begin to misfire and malfunction like wires with frayed insulation. But what triggers the body to attack the insulation in the nervous system in the first place is unknown.

More and more evidence has suggested that bacteria might be involved. The bacteria living in our guts can affect our immune system. And what we eat can affect the bacteria in our guts. Dr. Yanjiao Zhou at UConn Health School of Medicine collaborated with Dr. Laura Piccio from Washington University and now at the University of Sydney to study the gut microbiome, immune systems, diet, and blood metabolites in 49 volunteers—25 MS patients and 24 healthy controls—to look for correlations that might be subtle but important.

The strongest systemic linkage the researchers found involved eating meat. Their analysis linked higher meat consumption to a decrease in the population of Bacteroides thetaiotaomicron in people’s gut ecology. B. thetaiotaomicron is associated with digesting carbohydrates from vegetables.

Higher meat consumption, which was observed in the MS patients, was also linked to an increase in T-helper 17 cells in the immune system, and an increase in S-adenosyl-L-methionine (SAM) in their blood.

The relationship between meat-eating and disability and the other factors was not deterministic; some healthy people eat a lot of meat. But the pattern of all the factors was suggestive that, in MS, something goes wrong with people’s gut bacteria that dissociates them from the immune system, leading to heightened T-helper 17 cells and autoimmune attacks on the nervous system. And it tends to be associated with eating meat.

Release date: 27 January 2022
Source: University of Connecticut

Neurologic disorders, Neurologic disorders, Neurologic disorders, Neurologic disorders, Neurologic disorders, Neurologic disorders, Neurologic disorders, Neurologic disorders, Neurologic disorders, Neurologic disorders

Ultrasound Stimulation as an Effective Therapy for Alzheimer’s Disease

Synchronizing one’s brainwaves to ultrasound pulses could reduce the accumulation of abnormal proteins characteristic of the onset of Alzheimer’s diseaseAlzheimer’s disease affects over 50 million people worldwide and is presently incurable. A viable treatment strategy involves reducing abnormal protein accumulation in the brain with gamma waves. However, studies validating its therapeutic effects using non-focused ultrasound with gamma entrainment are lacking. Now, scientists from the Gwangju Institute of Science and Technology demonstrate reduced protein accumulation in the brain by synchronizing brain waves to external ultrasound pulses at gamma frequency, opening doors to a non-invasive therapy.With the increase in average life expectancy in many parts of the world, certain age-related diseases have become more common. Alzheimer’s disease (AD), unfortunately, is one of them, being extremely prevalent within aging societies in Japan, Korea, and various European countries. Currently there is no cure or an effective strategy to slow down the progression of AD. As a result, it causes much suffering to patients, families, and caregivers as well as a massive economic burden. Fortunately, a recent study by a team of scientists at the Gwangju Institute of Science and Technology (GIST) in Korea has just demonstrated that there might be a way to combat AD by using“ultrasound-based gamma entrainment,” a technique that involves syncing up a person’s (or an animal’s) brain waves above 30 Hz (called “gamma waves”) with an external oscillation of a given frequency. The process happens naturally by exposing a subject to a repetitive stimulus, such as sound, light, or mechanical vibrations.Previous studies on mice have shown that gamma entrainment could fight off the formation of β-amyloid plaques and tau protein accumulations—a standard hallmark of the onset of AD. In this recent paper, which was published in Translational Neurodegeneration, the GIST team demonstrated that it is possible to realize gamma entrainment by applying ultrasound pulses at 40 Hz, i.e., in the gamma frequency band, into the brain of an AD-model mice.

Release date: 20 January 2022
Source: GIST (Gwangju Institute of Science and Technology)