Mechanisms identified to restore myelin sheaths after injury or in multiple sclerosis

Researchers reveal a potential method for treating multiple sclerosis / Theophylline activates histone deacetylase, enabling the reconstruction of myelin sheaths.

A research team led by neurobiologist Professor Claire Jacob has identified an important mechanism that can be used to control the restoration of myelin sheaths following traumatic injury and in degenerative diseases. With the insights gained, the researchers were able to regenerate damaged myelin sheaths in mice by treating them with the active substance theophylline, thereby restoring their nerve cell function. The groundbreaking findings are the result of research carried out at Johannes Gutenberg University Mainz (JGU) and the University of Fribourg in Switzerland.