Studying the connections between meat, gut bacteria, and autoimmune attacks on the nervous system. Eating more meat, having less of certain bacteria in the gut, and more of certain immune cells in the blood, all link with multiple sclerosis, reports a team of researchers led by UConn Health and the Washington University School of Medicine. The work, published in issue of EBioMedicine, teased out subtle connections that could lead to a better understanding of the causes of the disease.
Multiple sclerosis (MS) is an autoimmune disease affecting fewer than 3 million people worldwide but costing $28 billion annually in the US alone—and untold suffering. MS is more prevalent in specific regions, particularly the northern mid-latitudes, suggesting that geography is somehow linked to the disease, perhaps involving diet. But teasing out the exact relationships between diet, immune response, and MS has been difficult. MS is most obviously an autoimmune disease in which the body attacks the insulation surrounding its nerves. When the insulation is damaged enough, the nerves begin to misfire and malfunction like wires with frayed insulation. But what triggers the body to attack the insulation in the nervous system in the first place is unknown.
More and more evidence has suggested that bacteria might be involved. The bacteria living in our guts can affect our immune system. And what we eat can affect the bacteria in our guts. Dr. Yanjiao Zhou at UConn Health School of Medicine collaborated with Dr. Laura Piccio from Washington University and now at the University of Sydney to study the gut microbiome, immune systems, diet, and blood metabolites in 49 volunteers—25 MS patients and 24 healthy controls—to look for correlations that might be subtle but important.
The strongest systemic linkage the researchers found involved eating meat. Their analysis linked higher meat consumption to a decrease in the population of Bacteroides thetaiotaomicron in people’s gut ecology. B. thetaiotaomicron is associated with digesting carbohydrates from vegetables.
Higher meat consumption, which was observed in the MS patients, was also linked to an increase in T-helper 17 cells in the immune system, and an increase in S-adenosyl-L-methionine (SAM) in their blood.
The relationship between meat-eating and disability and the other factors was not deterministic; some healthy people eat a lot of meat. But the pattern of all the factors was suggestive that, in MS, something goes wrong with people’s gut bacteria that dissociates them from the immune system, leading to heightened T-helper 17 cells and autoimmune attacks on the nervous system. And it tends to be associated with eating meat.
Release date: 27 January 2022
Source: University of Connecticut
Exercise can provide relief for dry, itchy eyes
A team led by researchers from the University of Waterloo discovered that a significant increase in tear secretion and tear film stability after participating in aerobic exercise can be another remedy for relieving dry, itchy eyes.
Every time we blink, our eyes are covered in tear film—an essential protective coating necessary for maintaining healthy ocular function. Healthy tear film comprises three layers–oil, water, and mucin–that work together to hydrate the ocular surface and protect against infection-causing irritants like dust or dirt.
When any part of the tear film becomes unstable, the ocular surface can develop dry spots, causing eye symptoms like itchiness or stinging and burning sensations.
“With so much of our activity tied to screen usage, dry eye symptoms are becoming increasingly common,” said Heinz Otchere, a PhD candidate in vision science at Waterloo. “Instead of having to use eye drops or other alternative treatments, our study aimed to determine if remaining physically active can be an effective preventative measure against dryness.”
Fifty-two participants were divided into two groups—athlete and non-athlete—to participate in an exercise session. Participants in the athlete group exercised at least five times per week, while non-athlete participants exercised no more than once per week. Researchers, which included experts from the University of Cape Coast in Ghana, performed visual examinations before and five minutes after each exercise session, where tear secretion and tear break-up time were assessed.
It was published in the Experimental Eye Research journal.
Release date: 03 February 2022
Source: university of Waterloo
Mechanism Revealed Behind Loss of Smell with COVID-19
Researchers have discovered a mechanism that may explain why people with COVID-19 lose their sense of smell.
Published online February 1 in the journal Cell, the new study finds that infection with the pandemic virus, SARS-CoV-2, indirectly dials down the action of olfactory receptors, proteins on the surfaces of nerve cells in the nose that detect the molecules associated with odors.
xperiments showed that the presence of the virus near nerve cells (neurons) in olfactory tissue brought an inrushing of immune cells, microglia, and T cells that sense and counter infection. Such cells release proteins called cytokines that changed the genetic activity of olfactory nerve cells, even though the virus cannot infect them, say the study authors. Where immune cell activity would dissipate quickly in other scenarios, in the brain, according to the team’s theory, immune signaling persists in a way that reduces the activity of genes needed for the building of olfactory receptors.
One unique symptom of COVID-19 infection is loss of smell without the stuffy nose seen with other infections like the common cold, researchers say. In most cases, the smell loss lasts only a few weeks, but for more than 12 percent of people with COVID-19, olfactory dysfunction persists in the form of ongoing reduction in the ability to smell (hyposmia) or changes in how a person perceives the same smell (parosmia).
To gain insight into COVID-19–induced smell loss, the current authors explored the molecular consequences of SARS-CoV-2 infection in golden hamsters and in olfactory tissue taken from 23 human autopsies. Hamsters represent a good model, being mammals that both depend more on the sense of smell than humans, and that are more susceptible to nasal cavity infection.
Release date: 02 February 2022
Source: NYU Grossman School of Medicine
Paternal Alcohol Use Increases Frequency Of Fetal Development Issues
Prenatal visits have traditionally focused almost exclusively on the behavior of mothers, but new research from the Texas A&M University College of Veterinary Medicine & Biomedical Sciences (CVMBS) continues to suggest that science should be looking more closely at the behavior of fathers as well.
Publication in The FASEB Journal , Golding’s team showed that the epigenetic factor of prenatal exposure to alcohol in males can manifest in the placenta.
According to Kara Thomas, VTPP graduate student and the lead author on the paper, their data shows that in mice, offspring of fathers exposed to alcohol have a number of placenta-related difficulties, including increased fetal growth restriction, enlarged placentas, and decreased placental efficiency.
“The placenta supplies nutrients to the growing fetus, so fetal growth restriction can be attributed to a less efficient placenta. This is why placental efficiency is such an important metric; it tells us how many grams of fetus are produced per gram of placenta,” Thomas said. “With paternal alcohol exposure, placentas become overgrown as they try to compensate for their inefficiency in delivering nutrients to the fetus.”
Release date: 01 February 2022
Source: Texas A&M University
Simpler and reliable ALS diagnosis with blood tests
Blood tests may enable more accurate diagnosis of ALS at an earlier stage of the disease. As described in a study by researchers at University of Gothenburg and Umeå University, it involves measuring the blood level of a substance that, as they have also shown, varies in concentration depending on which variant of ALS the patient has.
Currently, it is difficult to diagnose amyotrophic lateral sclerosis (ALS), the most common form of motor neuron disease, early in the course of the disease. Even after a prolonged investigation, there is a risk of misdiagnosis due to other diseases that may resemble ALS in early stages. Much would be gained from earlier correct diagnosis and, according to the researchers, the current findings look promising.
Neurofilaments — proteins with a special role in the cells and fibers of nerves — are the substances of interest. When the nervous system is damaged, neurofilaments leak into the cerebrospinal fluid (CSF) and in lower concetrations in blood compared to CSF. In their study, scientists at Umeå University and the University Hospital of Umeå, as well as at the University of Gothenburg and Sahlgrenska University Hospital in Gothenburg, demonstrated that CSF and blood levels of neurofilaments can differentiate ALS from other diseases that may resemble early ALS.
The study, published in Scientific Reports.
Release date: 26 January 2022
Source: University of Gothenburg
Cardiovascular risk of consuming small quantities of alcohol
Drinking less than the UK’s recommended limit of 14 units of alcohol per week still increases the risk of cardiovascular issues such as heart and cerebrovascular disease, according to new research published in the journal Clinical Nutrition.
The sample included 333,259 people who drank alcohol. Participants had been asked about their overall weekly alcohol intake and their intake of specific types of alcohol including beer, wine and spirits. Those participants were followed up for a median of approximately seven years, capturing all incidences where patients had been hospitalised through cardiovascular events.
Anyone who had suffered a previous cardiovascular event was excluded from the analysis, as were former drinkers or those who had not completed information on alcohol intake.
The analysis found that, for those participants that drank less than 14 units of alcohol per week – the limit recommended by the UK’s Chief Medical Officers – each additional 1.5 pints of beer at 4% strength (alcohol by volume) is associated with a 23% increased risk of suffering a cardiovascular event.
The authors argue that biases in existing epidemiological evidence have resulted in the widespread acceptance of the “J-shaped curve” that wrongly suggests low to moderate alcohol consumption can be beneficial to cardiovascular health.
These biases include using non-drinkers as a reference group when many do not drink for reasons of existing poor health, pooling of all drink types when determining the alcohol intake of a study population, and embedding the lower risk observed of coronary artery disease among wine drinkers, potentially distorting the overall cardiovascular risk from the drink.
Release date: 28 January 2022
Source: Anglia Ruskin University
Meat, Multiple Sclerosis, and the Microbiome
Studying the connections between meat, gut bacteria, and autoimmune attacks on the nervous system. Eating more meat, having less of certain bacteria in the gut, and more of certain immune cells in the blood, all link with multiple sclerosis, reports a team of researchers led by UConn Health and the Washington University School of Medicine. The work, published in issue of EBioMedicine, teased out subtle connections that could lead to a better understanding of the causes of the disease.
Multiple sclerosis (MS) is an autoimmune disease affecting fewer than 3 million people worldwide but costing $28 billion annually in the US alone—and untold suffering. MS is more prevalent in specific regions, particularly the northern mid-latitudes, suggesting that geography is somehow linked to the disease, perhaps involving diet. But teasing out the exact relationships between diet, immune response, and MS has been difficult. MS is most obviously an autoimmune disease in which the body attacks the insulation surrounding its nerves. When the insulation is damaged enough, the nerves begin to misfire and malfunction like wires with frayed insulation. But what triggers the body to attack the insulation in the nervous system in the first place is unknown.
More and more evidence has suggested that bacteria might be involved. The bacteria living in our guts can affect our immune system. And what we eat can affect the bacteria in our guts. Dr. Yanjiao Zhou at UConn Health School of Medicine collaborated with Dr. Laura Piccio from Washington University and now at the University of Sydney to study the gut microbiome, immune systems, diet, and blood metabolites in 49 volunteers—25 MS patients and 24 healthy controls—to look for correlations that might be subtle but important.
The strongest systemic linkage the researchers found involved eating meat. Their analysis linked higher meat consumption to a decrease in the population of Bacteroides thetaiotaomicron in people’s gut ecology. B. thetaiotaomicron is associated with digesting carbohydrates from vegetables.
Higher meat consumption, which was observed in the MS patients, was also linked to an increase in T-helper 17 cells in the immune system, and an increase in S-adenosyl-L-methionine (SAM) in their blood.
The relationship between meat-eating and disability and the other factors was not deterministic; some healthy people eat a lot of meat. But the pattern of all the factors was suggestive that, in MS, something goes wrong with people’s gut bacteria that dissociates them from the immune system, leading to heightened T-helper 17 cells and autoimmune attacks on the nervous system. And it tends to be associated with eating meat.
Release date: 27 January 2022
Source: University of Connecticut
COVID-19 Exposure Possible Outside of Home Isolation Rooms
A Rutgers study has detected tiny airborne particles containing RNA from the SARS-CoV-2 that causes COVID-19, both inside and outside of the rooms in which infected people were self-isolating at home. This finding suggests that airborne transmission beyond the isolation rooms in homes may pose a risk of infection to other home occupants.
The study, published in the journal Annals of the American Thoracic Society, is the first report of household air contamination with SARS-CoV2 RNA under typical daily living conditions when a household member is infected. Airborne transmission in crowded living conditions may be one reason for higher rates of COVID-19 infection among people with lower incomes.
“Risk of infection from larger respiratory droplets that rapidly settle onto surfaces, typically within two meters of the source, can be reduced by hand-washing, social distancing and face masks, but the tiny respiratory particles that stay suspended in air for hours, require air filtration, ventilation or better masks for prevention,” said lead author Howard Kipen.
The researchers collected air samples from 11 homes in rooms where a newly infected person was isolating, as well as in an adjacent common room to test for the presence of three SARS-CoV-2–specific genes in airborne particles. The researchers found positive air samples for at least one of three virus genes in six of the 11 isolation rooms and in six of the nine common rooms. Seven of these nine homes reported no other cases in the home.
To better understand how the virus spreads in the home, participants were asked to record their time in the isolation room and the common room. “We discovered that many did not strictly adhere to self-isolation, with eight of the 11 infected study participants reporting spending from a few hours to 14 hours in the common room and five of 11 participants reporting spending time in other areas of the home,” Kipen said. Additionally, in four of the homes other residents were also positive or had symptoms.
Release date: 27 January 2022
Source: Rutgers University
Predicting ‘Long COVID’ At Initial Point of COVID-19 Diagnosis
An ISB-led study has identified several factors that can predict if a patient is likely to develop long COVID. In this video, three of the paper’s authors – Dr. Jim Heath, Dr. Yapeng Su and Daniel Chen – discuss some of the implications of their work.
A significant portion of people who contract the SARS-CoV-2 virus – some estimates suggest more than 40 percent – suffer chronic effects known as Post Acute Sequelae of COVID-19 (PASC), commonly referred to as long COVID. PASC symptoms include fatigue, brain fog, the loss of taste and smell, shortness of breath, and more.
Now, researchers have identified several factors that can be measured at the initial point of COVID-19 diagnosis that anticipate if a patient is likely to develop long COVID. These “PASC factors” are the presence of certain autoantibodies, pre-existing Type 2 diabetes, SARS-CoV-2 RNA levels in the blood, and Epstein-Barr virus DNA levels in blood.
Additionally, researchers found that mild cases of COVID-19, not just severe cases, are associated with long COVID. They also suggest that administering antivirals very early in the disease course may potentially prevent some PASC.
“Long COVID is causing significant morbidity in survivors of COVID-19, yet the pathobiology is poorly understood,” said Dr. Jason Goldman, co-corresponding author of the paper and an infectious disease expert at Swedish. “Our study pairs clinical data and patient-reported outcomes with deep multi-omic analyses to unravel important biological associations that occur in patients with PASC. Certain findings such as the low cortisol state in patients with long COVID have potential to translate rapidly to the clinic. Our results form an important foundation for the development of therapeutics to treat long COVID.”
Published research paper in Cell.
Release date: 25 January 2022
Source: Institute for Systems Biology
AI can identify heart disease from an eye scan
Scientists have developed an artificial intelligence system that can analyse eye scans taken during a routine visit to an optician or eye clinic and identify patients at a high risk of a heart attack.
Doctors have recognised that changes to the tiny blood vessels in the retina are indicators of broader vascular disease, including problems with the heart.
In the research, led by the University of Leeds, deep learning techniques were used to train an AI system to automatically read retinal scans and identify those people who, over the following year, were likely to have a heart attack.
Deep learning is a complex series of algorithms that enable computers to identify patterns in data and to make predictions.
Writing in the journal Nature Machine Intelligence , the researchers report in their paper – Predicting Infarction through your retinal scans and minimal personal Information – that the AI system had an accuracy of between 70% and 80% and could be used as a second referral mechanism for in-depth cardiovascular examination.
The use of deep learning in the analysis of retinal scans could revolutionise the way patients are regularly screened for signs of heart disease.
Release date: 25 January 2022
Source: University of Leeds
Ultrasound Stimulation as an Effective Therapy for Alzheimer’s Disease
Synchronizing one’s brainwaves to ultrasound pulses could reduce the accumulation of abnormal proteins characteristic of the onset of Alzheimer’s diseaseAlzheimer’s disease affects over 50 million people worldwide and is presently incurable. A viable treatment strategy involves reducing abnormal protein accumulation in the brain with gamma waves. However, studies validating its therapeutic effects using non-focused ultrasound with gamma entrainment are lacking. Now, scientists from the Gwangju Institute of Science and Technology demonstrate reduced protein accumulation in the brain by synchronizing brain waves to external ultrasound pulses at gamma frequency, opening doors to a non-invasive therapy.With the increase in average life expectancy in many parts of the world, certain age-related diseases have become more common. Alzheimer’s disease (AD), unfortunately, is one of them, being extremely prevalent within aging societies in Japan, Korea, and various European countries. Currently there is no cure or an effective strategy to slow down the progression of AD. As a result, it causes much suffering to patients, families, and caregivers as well as a massive economic burden. Fortunately, a recent study by a team of scientists at the Gwangju Institute of Science and Technology (GIST) in Korea has just demonstrated that there might be a way to combat AD by using“ultrasound-based gamma entrainment,” a technique that involves syncing up a person’s (or an animal’s) brain waves above 30 Hz (called “gamma waves”) with an external oscillation of a given frequency. The process happens naturally by exposing a subject to a repetitive stimulus, such as sound, light, or mechanical vibrations.Previous studies on mice have shown that gamma entrainment could fight off the formation of β-amyloid plaques and tau protein accumulations—a standard hallmark of the onset of AD. In this recent paper, which was published in Translational Neurodegeneration, the GIST team demonstrated that it is possible to realize gamma entrainment by applying ultrasound pulses at 40 Hz, i.e., in the gamma frequency band, into the brain of an AD-model mice.
Release date: 20 January 2022
Source: GIST (Gwangju Institute of Science and Technology)