https://azharimd.com/wp-content/uploads/2020/09/Stronger-bones-thanks-to-heat-and-microbiota-تاثیر-آب-و-هوا-بر-پوکی-استخوان.jpg 430 1200 دکتر امین اظهری https://azharimd.com/wp-content/uploads/2018/07/Dr-Azhar-279x300.png دکتر امین اظهری2020-09-22 08:03:432020-09-21 11:50:53Stronger bones thanks to heat and microbiota
Osteoporosis, a bone disease linked to ageing, is characterised by a loss of bone density, micro-architectural deterioration of the bones and an increased risk of fractures. With one third of postmenopausal women affected, it is a major public health problem. Through epidemiological analyses, laboratory experiments and state-of-the-art metagenomic and metabolomics tools, a research team has observed that exposure to warmer ambient temperatures (34 °C) increases bone strength, while preventing the loss of bone density typical of osteoporosis. Moreover, this phenomenon, linked to a change in the composition of gut microbiota triggered by heat, could be replicated by transplanting the microbiota of mice living in a warm environment to mice suffering from osteoporosis. Indeed, after the transplant, their bones were stronger and denser. These results, to be discovered in Cell Metabolism, make it possible to imagine effective and innovative interventions for prevention and treatment of osteoporosis.
Release date: 10 September 2020
Source: Université de Genève