Sport Medicine Archives - Dr Amin Azhari - دکتر امین اظهری

Intense exercise while dieting may reduce cravings for fatty food

In a study that offers hope for human dieters, rats on a 30-day diet who exercised intensely resisted cues for favored, high-fat food pellets.

The experiment was designed to test resistance to the phenomenon known as “incubation of craving,” meaning the longer a desired substance is denied, the harder it is to ignore signals for it. The findings suggest that exercise modulated how hard the rats were willing to work for cues associated with the pellets, reflecting how much they craved them.

While more research needs to be done, the study may indicate that exercise can shore up restraint when it comes to certain foods, said Travis Brown, a Washington State University physiology and neuroscience researcher.

“A really important part of maintaining a diet is to have some brain power—the ability to say ‘no, I may be craving that, but I’m going to abstain,’” said Brown, corresponding author on the study published in the journal Obesity. “Exercise could not only be beneficial physically for weight loss but also mentally to gain control over cravings for unhealthy foods.”

In the experiment, Brown and colleagues from WSU and University of Wyoming put 28 rats through a training with a lever that when pressed, turned on a light and made a tone before dispensing a high-fat pellet. After the training period, they tested to see how many times the rats would press the lever just to get the light and tone cue.

Release date: 21 April 2022
Source: Washington State University

Stop the clocks: Brisk walking may slow biological ageing process

Brisk walking may slow biological ageing process - ورزش کاهنده سرعت ساعت بیولوژیک

A new study of genetic data published today (Wednesday) of more than 400,000 UK adults has revealed a clear link between walking pace and a genetic marker of biological age.

Confirming a causal link between walking pace and leucocyte telomere length (LTL) – an indicator of biological age – the Leicester-based team of researchers estimate that a lifetime of brisk walking could lead to the equivalent of 16 years younger biological age by midlife.

Researchers from the University of Leicester at the National Institute for Health and Care Research (NIHR) Leicester Biomedical Research Centre studied genetic data from 405,981 middle-aged UK Biobank participants and found that a faster walking pace, independent of the amount of physical activity, was associated with longer telomere.

Telomeres are the ‘caps’ at the end of each chromosome, and hold repetitive sequences of non-coding DNA that protect the chromosome from damage, similar to the way the cap at the end of a shoelace stops it from unravelling.

Each time a cell divides, these telomeres become shorter – until a point where they become so short that the cell can no longer divide, known as ‘replicative senescence’. Therefore, scientists consider LTL a strong marker for ‘biological age’, independent from when an individual was born.

Release date: 20 April 2022
Source: University of Leicester

Exercise During Pregnancy Reduces the Risk of Type-2 Diabetes in Offspring

A new study has demonstrated that maternal exercise during pregnancy improves the metabolic health of offspring, even when the mother is obese or on a high-fat diet. Physical exercise by the mother induces the placenta to secrete the key protein SOD3, resulting in a lowered risk of diabetes for the offspring. The findings in the paper identified the mechanisms behind this process.

The results were published in the Journal Diabetes.

Release date: 14 April 2022
Source: Tohoku University

Sitting Tai Chi exercises improved recovery outcomes for older stroke survivors

A study in China found that after three months of practicing a modified form of Tai Chi in which participants are seated, stroke survivors had improved hand and arm function, sitting balance, mental health and quality of life, compared to stroke survivors who participated in a standard stroke rehabilitation exercise program.
The study is the first randomized controlled trial to indicate practicing a seated form of Tai Chi early after a stroke enhanced health outcomes.
Stroke survivors who practiced a seated form of Tai Chi had equal or greater improvement in hand and arm strength, shoulder range of motion, balance control, symptoms of depression and activities of daily living after three months, compared to those who participated in a standard stroke rehabilitation exercise program, according to new research published today in Stroke, the peer-reviewed flagship journal of the American Stroke Association, a division of the American Heart Association.

The American Heart Association’s/American Stroke Association’s Guidelines for the Early Management of Patients with Acute Ischemic Stroke recommend people start stroke rehabilitation within seven days and continue for up to six months after a stroke. However, many survivors opt out of rehabilitation therapy because they lack physical stability or are unable to fully use their arms. The Association also notes in a Scientific Statement about Physical Activity and Exercise Recommendations for Stroke Survivors that flexibility and muscle strength training, including yoga and Tai Chi, are reported to be beneficial for stroke survivors in improving balance, quality of life and mental health, while reducing the fear of falling.

Tai Chi, a traditional Chinese martial art, consists of a series of slow, careful movements of the hands, arms, neck, legs and core combined with deep breathing. The novelty of this study is that researchers developed a sitting routine of Tai Chi exercises for people who had a recent ischemic stroke (blocked blood vessel to the brain) and experienced hand and arm weakness or partial paralysis.

Release date: 07 April 2022
Source: American Heart Association

Neurologic disorders

Researchers discover new neurodevelopmental disorder

Australian researchers have discovered a new neurodevelopmental disorder after uncovering its link to a tumor suppressor gene.

The international research collaboration, led by the Murdoch Children’s Research Institute (MCRI) and published in The American Journal of Human Genetics, has linked a recognised tumor suppressor gene to a new neurodevelopmental syndrome, ending the diagnostic journey for 32 families around the world.

The study found variations in the FBXW7 gene were associated with the newly identified condition, which causes mild to severe developmental delay, intellectual disability, hypotonia and gastrointestinal issues.

Murdoch Children’s researcher Dr Sarah Stephenson said because the FBXW7 gene regulated the life-cycle of cells, cell growth and survival, the research team speculated that abnormal cell proliferation during brain development may underpin the broad spectrum of brain abnormalities identified in this new disorder.

The study used cutting-edge diagnostic tools, genomic sequencing and global data-sharing platforms to identify 35 people, aged 2-44 years, from 32 families in seven countries harbouring the FBXW7 gene, which had variants that were associated with the never-before described neurodevelopmental syndrome.

Almost all affected people had developmental delay and intellectual disability, ranging from borderline to severe, 62 per cent had decreased muscle tone, 46 per cent noted feeding difficulties and constipation and 23 per cent had seizures. Brain imaging also detailed variable underlying structural differences affecting the cerebellum, nerve fibres and white matter.

The team then reduced the gene’s levels in a fly model, which affected the flies’ ability to jump in response to a stimulus. This supported the observation that the 28 variants in FBXW7 were the cause of the condition. It also further cemented the fundamental role of the gene in development broadly, and the brain, specifically.

Release date: 08 April 2022
Source: Murdoch Childrens Research Institute

Sport improves concentration and quality of life

Study with primary school pupils confirms positive impact of physical fitness. Physically fit primary school pupils feel better and can concentrate better. They are more likely to make it to higher-level secondary grammar schools than children with less sporting abilities. This has been confirmed for the first time in a study by the Department of Sport and Health Sciences at the Technical University of Munich (TUM).

Movement on a regular basis keeps kids healthy and fit for school. The benefits of sports have been demonstrated in numerous studies. Now a research team at the TU Munich has found proof of the correlation between physical fitness, concentration and health-related quality of life for primary school pupils.

The study involved 3285 girls and 3248 boys from Bavaria’s Berchtesgadener Land district. The key criteria were physical strength and endurance, the ability to concentrate and health-related quality of life, as determined by the scientists according to internationally standardized test procedures. Journal of Clinical Medicine

Release date: 05 April 2022
Source: Technical University of Munich (TUM)

Exercise may reduce depression symptoms, boost effects of therapy

Exercising for half an hour may reduce symptoms of depression for at least 75 minutes post-workout and amplify the benefits of therapy, according to two new studies led by researchers at Iowa State University.

For the first study, the researchers recruited 30 adults who were experiencing major depressive episodes. The participants filled out electronic surveys immediately before, half-way-through and after a 30-minute session of either moderate-intensity cycling or sitting, and then 25-, 50- and 75-minutes post-workout. Those who cycled during the first lab visit came back a week later to run through the experiment again with 30-minutes of sitting, and vice versa.

Each survey included standard questions and scales used to measure symptoms of depression and several cognitive tasks, including the Stroop test; participants responded to the color of a particular font rather than the word itself (e.g., indicating red when they saw the word ‘blue’ in red ink).

During the cycling experiment, participants’ depressed mood state improved over the 30 minutes of exercise and consistently up to 75 minutes afterward. The improvement to anhedonia started to drop off at 75 minutes post-exercise, but still was better than the participants’ levels of anhedonia in the group that did not exercise.

As for cognitive function, participants who cycled were faster on the Stroop test mid-exercise but relatively slower 25- and 50-minutes post-exercise compared to participants in the resting group. Meyer said more research is needed to understand the variation.

Half of the ten participants exercised on their own (e.g., cycled, jogged, walked) for 30 minutes at a pace they considered moderate intensity, which the researchers also verified with Fitbit data, before signing into an hour of virtual, cognitive behavior therapy each week. The other participants simply continued in their day-to-day activities prior to their therapy sessions.

At the end of the eight-week intervention program, participants in both groups showed improvements, but those who exercised before talking with a therapist had more pronounced reductions in symptoms of depression.

The researchers said the results indicate exercise could help amplify the benefits of therapy for adults with depression. Psychology of Sport and Exercise

Release date: 30 March 2022

Source: Iowa State University

Neurologic disorders, Neurologic disorders

Physical activity may protect your brain as you age

Even just a few more steps a day benefits cognitive function

We all know we should exercise and eat healthy. But doing that isn’t just good for maintaining your figure as you age.

New research from the University of Georgia shows that physical activity could help protect your cognitive abilities as you age. And it doesn’t have to be intense exercise to make an impact.

Exercise improves brain function
Published in Sport Sciences for Health, the study followed 51 older adults, tracking their physical activity and fitness measurements. The participants performed tests specifically designed to measure cognitive functioning and underwent MRIs to assess brain functioning.

They also wore a device that measured the intensity of the wearer’s physical activity, number of steps taken and distance covered. The researchers assessed fitness through a six-minute walking test, during which participants walked as quickly as they could to cover the most distance possible within the time limit.

Release date: 08 March 2022
Source: University of Georgia

Public Health

PHYSICAL FITNESS LINKED TO LOWER RISK OF ALZHEIMERS DISEASE

“One exciting finding of this study is that as people’s fitness improved, their risk of Alzheimer’s disease decreased—it was not an all-or-nothing proposition,” said study author Edward Zamrini, MD, of the Washington VA Medical Center in Washington, D.C., and a member of the American Academy of Neurology. “So people can work toward making incremental changes and improvements in their physical fitness and hopefully that will be associated with a related decrease in their risk of Alzheimer’s years later.”

The study involved 649,605 military veterans in the Veterans Health Administration database with an average age of 61 who were followed for an average of nine years. They did not have Alzheimer’s disease at the start of the study.

Researchers determined participants’ cardiorespiratory fitness. Cardiorespiratory fitness is a measure of how well your body transports oxygen to your muscles, and how well your muscles are able to absorb oxygen during exercise.

The participants were divided into five groups, from least fit to most fit. Fitness levels were determined by how well participants did on a treadmill test. This test measures exercise capacity, the highest amount of physical exertion a person can sustain. For people who are middle-aged and older, the highest level of fitness can be achieved by walking briskly most days of the week, for two and a half hours or more per week.

The group with the lowest level of fitness developed Alzheimer’s at a rate of 9.5 cases per 1,000 person-years, compared to 6.4 cases per 1,000 person-years for the most fit group. Person-years take into account the number of people in a study as well as the amount of time spent in the study. The case rate decreased as the level of fitness increased, with a rate of 8.5 for the second least fit group, 7.4 for the middle group and 7.2 for the second most fit group.

When researchers adjusted for other factors that could affect risk of Alzheimer’s disease, they found that the people in the most fit group were 33% less likely to develop Alzheimer’s disease than those in the least fit group. The second most fit group was 26% less likely to develop the disease, while the middle group was 20% less likely and those in the second least fit group were 13% less likely to develop the disease than those in the least fit group.

Release date: 27 February 2022
Source: American Academy of Neurology

Covid-19, Public Health, Public Health, Public Health, Public Health, Public Health, Public Health, Public Health

Exercise post-vaccine bumps up antibodies

Researchers at Iowa State University found 90 minutes of mild- to moderate-intensity exercise directly after a flu or COVID-19 vaccine may provide an extra immune boost.

In the newly published study, participants who cycled on a stationary bike or took a brisk walk for an hour-and-a-half after getting a jab produced more antibodies in the following four weeks compared to participants who sat or continued with their daily routine post-immunization. The researchers found similar results when they ran an experiment with mice and treadmills.

Antibodies are essentially the body’s “search and destroy” line of defense against viruses, bacteria, fungi and parasites. Vaccines help the immune system learn how to identify something foreign and respond by bolstering the body’s defenses, including an increase in antibodies.

“Our preliminary results are the first to demonstrate a specific amount of time can enhance the body’s antibody response to the Pfizer-BioNtech COVID-19 vaccine and two vaccines for influenza,” said Kinesiology Professor Marian Kohut, lead author of the paper published in the journal Brain, Behavior, and Immunity.

The researchers said the study’s findings could directly benefit people with a range of fitness levels. Nearly half of the participants in the experiment had a BMI in the overweight or obese category. During 90 minutes of exercise, they focused on maintaining a pace that kept their heart rate around 120–140 beats per minute rather than distance.

In the study, the researchers also tested whether participants could get the same bump in antibodies with just 45-minutes of exercising. They found the shorter workout did not increase the participants’ antibody levels. Kohut said the research team may test whether 60 minutes is enough to generate a response in a follow-up study.

Release date: 11 February 2022
Source: Iowa State University