Public Health

Waking just one hour earlier cuts depression risk by double digits - خواب صبح و افسردگی

Waking up just one hour earlier could reduce a person’s risk of major depression by 23%, suggests a sweeping new genetic study published May 26 in the journal JAMA Psychiatry.

The study of 840,000 people, by researchers at University of Colorado Boulder and the Broad Institute of MIT and Harvard, represents some of the strongest evidence yet that chronotype–a person’s propensity to sleep at a certain time –influences depression risk.

It’s also among the first studies to quantify just how much, or little, change is required to influence mental health.

As people emerge, post-pandemic, from working and attending school remotely– a trend that has led many to shift to a later sleep schedule–the findings could have important implications.

 

Release date: 28 May 2021
Source: EurokAlert

Vitamin D may not protect against COVID19 - تردیدها درباره نقش ویتامین D در کرونا

While previous research early in the pandemic suggested that vitamin D cuts the risk of contracting COVID-19, a new study from McGill University finds there is no genetic evidence that the vitamin works as a protective measure against the coronavirus.

To assess the relationship between vitamin D levels and COVID-19 susceptibility and severity, the researchers conducted a Mendelian randomization study using genetic variants strongly associated with increased vitamin D levels. They looked at genetic variants of 14,134 individuals with COVID-19 and over 1.2 million individuals without the disease from 11 countries. The researchers found that among people who did develop the disease, there was no difference between vitamin D levels and a likelihood of being hospitalized or falling severely ill.

In the study published in PLOS Medicine.

Release date: 04 June 2021
Source: McGill University

Narcissism linked to aggression - خودشیفتگی و خشونت

A comprehensive analysis of 437 studies from around the world provides the best evidence to date that narcissism is an important risk factor for both aggression and violence, researchers said.

The link between narcissism and aggression was found for all dimensions of narcissism and for a variety of types of aggression. Results were similar regardless of gender, age, whether they were college students, or country of residence. And, to have an impact, narcissism doesn’t have to be at levels so high as to be pathological. Findings showed that even when narcissism was within what is considered a normal range, higher levels were linked to aggression.

It was published in the journal Psychological Bulletin.

Release date: 25 May 2021
Source: Ohio State University

Obesity protects against death in severe bacterial infection - از مزیت های چاقی

For many diseases, overweight and obesity are risk factors. But now a study shows that a higher BMI may be linked to higher survival rates in patients hospitalized for severe bacterial infections.

The population-based study involved observations, over a nine-month period, of all 2,196 individual adults receiving care for suspected severe bacterial infection at Skaraborg Hospital in Skövde. The researchers followed the patients in this study population over time, during and after their hospital stay.

The results show that the raised chances of survival were associated with a higher body mass index (BMI) in both the short and long term, at 28 days and one year after hospitalization respectively. The differences in survival rates were clear. In the normal-weight group, 26 percent were dead within a year. The corresponding figures in the groups with higher BMI were 9–17 percent.

This study has now been published in the journal PLOS ONE.

Release date: 20 May 2021
Source: University of Gothenburg

Will COVID19 Eventually Become Just a Seasonal Nuisance - فرجام احتمالی کرونا

Within the next decade, the novel coronavirus responsible for COVID-19 could become little more than a nuisance, causing no more than common cold-like coughs and sniffles. That possible future is predicted by mathematical models that incorporate lessons learned from the current pandemic on how our body’s immunity changes over time. Scientists at the University of Utah carried out the research, now published in the journal Viruses.

Release date: 20 May 2021
Source: University of Utah Health

Step closer to nasal spray drug delivery for Parkinsons disease - درمان جدید پارکینسون در راه

Scientists at the University of York have made significant progress in the development of a nasal spray treatment for patients with Parkinson’s disease.

Researchers have developed a new gel that can adhere to tissue inside the nose alongside the drug levodopa, helping deliver treatment directly to the brain.

Levodopa is converted to dopamine in the brain, which makes-up for the deficit of dopamine-producing cells in Parkinson’s patients, and helps treat the symptoms of the disease. Over extended periods of time, however, levodopa becomes less effective, and increased doses are needed. Advanced Science 

Release date: 24 May 2021
Source: University of York

Women with Osteoporosis and Low Bone Density Are at Increased Risk of Hearing Loss - ارتباط سلامت استخوان و گوش

Hearing loss is the third most common chronic health condition in the United States. Previous studies of people with hearing loss have uncovered higher prevalence of osteoporosis — a disease in which the bones become weak and brittle — and low bone density (LBD). But research on whether these conditions may influence risk of hearing loss over time is scarce. It is also unknown whether hearing loss can be avoided by taking bisphosphonates, the primary medication used to prevent fractures in people with reduced bone density. As part of the Conservation of Hearing Study (CHEARS), researchers from Brigham and Women’s Hospital analyzed data from nearly 144,000 women who were followed for up to 34 years. They found that risk of subsequent moderate or worse hearing loss was up to 40 percent higher in study participants with osteoporosis or LBD. The study, published in the Journal of the American Geriatrics Society, also found that bisphosphonates did not alter risk of hearing loss.

Release date: 24 May 2021
Source: Brigham and Women’s Hospital

For men low testosterone means high risk of severe COVID19 - کرونا در مردان

Throughout the pandemic, doctors have seen evidence that men with COVID-19 fare worse, on average, than women with the infection. One theory is that hormonal differences between men and women may make men more susceptible to severe disease. And since men have much more testosterone than women, some scientists have speculated that high levels of testosterone may be to blame.

But a new study from Washington University School of Medicine in St. Louis suggests that, among men, the opposite may be true: that low testosterone levels in the blood are linked to more severe disease. The study could not prove that low testosterone is a cause of severe COVID-19; low levels could simply serve as a marker of some other causal factors. Still, the researchers urge caution with ongoing clinical trials investigating hormonal therapies that block or lower testosterone or increase estrogen as a treatment for men with COVID-19.

The study appears in JAMA Network Open.

Release date: 25 May 2021
Source: Washington University School of Medicine

Alcohol May Have Immediate Effect on Atrial Fibrillation Risk - از عوارض حاد مصرف مشروبات الکلی

Alcohol appears to have an immediate—or near-immediate—effect on heart rhythm, significantly increasing the chance that an episode of atrial fibrillation (AFib) will occur, according to new data presented at the American College of Cardiology’s 70th Annual Scientific Session.
The data revealed that just one glass of wine, beer or other alcoholic beverage was associated with twofold greater odds of an episode of AFib occurring within the next four hours. Among people having two or more drinks in one sitting, there was a more than threefold higher chance of experiencing AFib. Using an alcohol sensor placed on participants’ ankles, which passively monitored alcohol intake, the investigators found that every 0.1% increase in inferred blood alcohol concentration over the previous 12 hours was associated with an approximate 40% higher odds of an AFib episode. Evidence from those sensors also demonstrated that the total alcohol concentration over time also predicted the chance AFib would occur.

Release date: 17 May 2021
Source: American College of Cardiology

Overweight boy watching others in gym class

Higher body mass index (BMI) – an indicator of obesity – in late adolescence is associated with a significantly higher risk of first ischemic stroke in men and women under age 50, regardless of whether they had Type 2 diabetes.
Even BMIs in the high-normal range are associated with increased stroke risk in both men and women.

During the follow-up period, for all 1.9 M participants between 2014 and 2018, researchers found:

Overall, 1,088 strokes occurred (921 ischemic strokes, 167 hemorrhagic strokes), and the average age at the time of the stroke was 41. Adolescent BMI was directly related to the risk of first ischemic stroke.
Compared to participants in the low-normal BMI group, adolescents who were in the overweight category had a 2-times higher stroke risk before the age of 50, and adolescents with obesity had a 3.4-times higher risk.
Even adolescents with BMIs in the high-normal range were more likely to have a stroke before age 50 compared to those in the low-normal BMI group.
After accounting for Type 2 diabetes, adolescents who were in either the overweight or obesity category still had a higher risk of stroke (1.6-times and 2.4-times, respectively) compared to people who had BMI values within the normal range. Stroke

Release date: 13 May 2021
Source: American Heart Association